The adult magazine has featured women from corporations in the past, whether because of controversy, as was the case with Enron and WorldCom, or because the company is an industry icon, such as Starbucks or Wal-Mart.
"These companies have thousands and thousands of employees, and there are many beautiful women among them," Playboy.com spokeswoman Jay Jay Nesheim said, adding that women interested should submit photos, proof of age and a paycheck stub.
Home Depot is distancing itself from the photo shoot.
"The company is aware of the invitation but does not endorse it, support it, nor are we affiliated with it in any way," spokesman Don Harrison said, reading a prepared statement over the phone and refusing to comment further.
Playboy heard no complaints of women being fired for the Starbucks or Wal-Mart shoots, Nesheim said.
No happy homemakers for Playboy, I guess.