The virus, which kills anywhere between 50 and 90 percent of victims, is still rare but the most recent outbreak in Congo Republic has killed at least 11 people in a remote forest region.
It is considered a threat because it is deadly, highly infectious and has no treatment. U.S. experts fear it could also be used as a biological weapon.
The U.S. National Institute of Allergy and Infectious Diseases will test the vaccine for safety in about two dozen volunteers.
The vaccine, made by San Diego-based Vical Inc., has so far fully protected monkeys from the virus. It uses pieces of DNA from the virus to prime the immune system.
Big news indeed, if the trials are successful.